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      Cost of generic bupropion on its behalf, a difference that could translate into millions of dollars in extra tax for those states, according to the study. company didn't respond to requests for comment. The FDA recently approved bupropion for the treatment of sleep disorder insomnia. In October, it took on the drug in an effort to ease the financial burden of addiction for many the nation's roughly 30 million patients. The review found that at end of 2013, the average annual cost of a generic drug for treatment of substance dependence was $622, according to the study, conducted by Center for Studying Drug Development at Brandeis University. That's more than $1,200 its price of $499 in 2006, before the FDA allowed generic versions to be sold over the counter. Bupropion has long been approved for a different type of addiction, post-traumatic stress disorder, or PTSD, for which it is used to treat at least 20,000 troops. The Brandeis researchers calculated that if the agency approved bupropion for those with addiction, it could spend about $6.4 billion on prescription drugs to treat those with addictions. That would be an 18 percent increase — and a significant sum compared to the other drugs they took into account. "We found there were a lot of other compounds on markets that were more expensive," said study co-author Mark F. Price, dean of the university's School Pharmacy and Administration. The new analysis is expected to get some pushback, since the FDA's approval of bupropion for the treatment opiate addiction came on the heels of a long federal political battle that helped win approval for a generic version of the drug. A similar discussion is likely to play out over generic bupropion for alcohol addiction, as well any other opioid addiction treatments. Bupropion is still widely sold over-the-counter, and its list price has held steady. Some health insurers and employers also may have bought the drug without paying full list price. The study authors say they are particularly concerned that some states may see extra sales revenue as a result of generic version bupropion now available. They did not take the impact of generic bupropion into account in the new estimate though. "There will be an argument that some states may see an increase as the list price for bupropion falls," said. "In all seriousness, however, it's important to note that most states already have generic bupropion available, so this might not have a big affect on the local markets." But other experts cautioned that generic bupropion is only one of many options to treat addiction. For that reason, they say, it is important to have an open discussion about the best options. "I think that generic bupropion is only one option," said William K. Mariano, president of the American Society Addiction Medicine, which advocates for improved treatment of substance abuse. "Some people might want bupropion to be the primary medication for addiction, and then others might be willing to consider the other drug options on market or consider alternative approaches that are more effective," Mariano said. "That's one of the many issues that comes with these negotiations, and we need to have an honest conversation about the other options that are out there." Other health economists said they were not surprised by the study findings, given political and marketing battles that have shaped the generic bupropion market over years. "It was an drugstore shampoo hair loss industry-driven situation from the beginning, and it's still been a competitive market, since it was originally developed as a medication for PTSD," said Mark Olfson, a professor of international health at Columbia University. "There was no serious question to the generics industry that there was no real benefit to generic bupropion for treating addiction," he said. Olfson points to the research of Mark Schoener, a Princeton University professor who examined the drug's effectiveness in treating obesity. Schoener's reviews found that bupropion had no significant metabolic effect on patients who lost at least 10 percent of their body weight after using the medicine. In 2014, the U.S. Food and Drug Administration approved a generic version of.

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