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      Maxitrol generic equivalent ) in the second-morning sample (n = 15). FIGURE 1 View largeDownload slide Mean (±SEM) concentrations of testosterone (A) and estradiol (B) released from human serum and muscle (n = 6). Results are means ± SEM, *p < 0.05 compared with placebo. FIGURE 2 View largeDownload slide Concentrations of testosterone (A) and estradiol (B) released from mouse drug store shampoo for hair loss plasma (n = 5). FIGURE 3 View largeDownload slide Concentrations of testosterone (A) and estradiol (B) released from human skeletal muscle (n = 6). The effects of testosterone on muscle growth and function in postmenopausal women are illustrated Figure 4. Two weeks after beginning testosterone therapy (0.1 mg daily oral for 6 months, n = 9), the cross-sectional area of vastus lateralis (VL) increased by 2.5% (P < 0.001) and the muscle thickness increased by 6.8mm (P < 0.001). After 16 weeks of therapy (1.0 mg, n = 9), the cross-sectional area of VL increased by 2.1% (P < 0.001) and the muscle thickness increased by 7.8mm (P < 0.001). After 24 weeks of therapy (1.4 mg daily, n = 8), the cross-sectional area of VL increased by 4% (P < 0.001) and the muscle thickness increased by 11mm (P < 0.001). The magnitude of these changes in the area of VL and thickness muscle was greater in the women treated with testosterone than in the placebo group, while there were no differences in the magnitude of any these changes between age groups (P > 0.05). FIGURE 4 View largeDownload slide Changes in muscle volume postmenopausal women receiving 1.0 mg testosterone gavage, 0.1 daily Buy maxitrol eye drops uk oral, or 1.4 mg (n = 9). The data are means ± SEMs; n = 9 were tested in the first-morning sample. The effects of testosterone on muscle strength are illustrated in Figure 5. The change VL from baseline to week 16 was greater in the women receiving testosterone than in the placebo group (P < 0.05), but the changes in muscle thickness were greater the women receiving testosterone than in the placebo group (P < 0.05). FIGURE 5 View largeDownload slide Changes in knee extension strength postmenopausal women receiving 0.1 mg daily oral for 6 months, or 1.4 mg daily (n = 9) or placebo 11). The data are means ± SEMs; n = 9 were tested in the first-morning sample. Effects of Testosterone on Bone Mass The changes in bone mass were assessed during the 8-wk treatment period (Figure 6). There were no differences in the changes total bone mass between the placebo and testosterone groups. FIGURE 6 View largeDownload slide Changes in trabecular bone volume postmenopausal women receiving 0.1 mg daily oral for 6 months, or 1.4 mg daily (n = 9) or placebo 11). The data are means ± SEMs; n = 9 were tested in the first-morning sample. Effects of Testosterone on Strength (1RM) and Muscular.



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